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Joline E. Brandenburg, M.D., Physical Medicine and Rehabilitation, discusses the rationale for studying passive muscle stiffness, the effects of spasticity on muscle in children with cerebral palsy.
Jay Smith, M.D., describes a clinical trial to evaluate the safety and efficacy of adipose-derived mesenchymal stromal cell injections as a treatment for people with osteoarthritic knees.
Mayo Clinic researchers have discovered that targeting select pathways with JAK inhibitors reduced inflammation in human cells in culture dishes and decreased inflammation and frailty in aged mice.
James L. Kirkland, M.D., Ph.D., discusses a study finding a new class of drugs, identified and validated by Mayo Clinic researchers and their collaborators, clearly reduces health problems in mice by limiting the effect of senescent cells.
By examining more than 3,600 postmortem brains, researchers at Mayo Clinic have found that the progression of dysfunctional tau protein drives the cognitive decline and memory loss seen in Alzheimer's disease.
Research suggests that some acutely injured kidneys from donors who are deceased can be used for transplant with safe, positive outcomes.