Liver Transplant for ATTRm

Mayo Clinic hematologist, Angela Dispenzieri, M.D., discusses liver transplant for transthyretin amyloidosis.  Visit here to learn more about transthyretin amyloidosis or to make an appointment.   

Amyloidosis is a disease where abnormal proteins form fibrils and deposit in organs such as the heart and kidneys.  Transthyretin is a normal protein that is made in the liver.  Those proteins are then circulated in the blood.  This is a normal process, however, if an inherited abnormality is introduced, the pathway is changed and these proteins can deposit into the organs causing people to feel unwell.  Symptoms of transthyretin amyloidosis are shortness of breath, changes in bowel habits, reduced exercise stamina, and numbness or tingling.

Treatment for transthyretin amyloidosis can include liver transplantation done through a donor program or through a living donor.

Video Content Outline:

· Introduction
· What is transthyretin amyloidosis (0:42)
· Why liver transplant (6:03)
· How liver transplant (7:36)
· Results (10:46)
· Alternative options (13:00)
· Conclusion (16:13)

 


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Mayo Clinic

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Angela Dispenzieri, MD

Angela Dispenzieri, MD

Conditions treated Amyloidosis Cryoglobulinemia Monoclonal gammopathy of undetermined significance Multiple myeloma Osteosclerotic myeloma POEMS syndrome Interests Multiple myeloma Monoclonal gammopathy Cryoglobulinemia Osteosclerotic ...

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