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Mayo Clinic researchers have discovered that targeting select pathways with JAK inhibitors reduced inflammation in human cells in culture dishes and decreased inflammation and frailty in aged mice.
James L. Kirkland, M.D., Ph.D., discusses a study finding a new class of drugs, identified and validated by Mayo Clinic researchers and their collaborators, clearly reduces health problems in mice by limiting the effect of senescent cells.
By examining more than 3,600 postmortem brains, researchers at Mayo Clinic have found that the progression of dysfunctional tau protein drives the cognitive decline and memory loss seen in Alzheimer's disease.
Research suggests that some acutely injured kidneys from donors who are deceased can be used for transplant with safe, positive outcomes.
Mayo Clinic researcher Fergus J. Couch, Ph.D., discusses a study show that combined 77 common genetic variants into a single risk factor that can be used to improve the identification of women with an elevated risk of breast cancer.
Herceptin has been touted as a wonder drug for women with HER2-positive breast cancer, an aggressive form of the disease that is fueled by excess production of the HER2 protein.