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SAMAR IBRAHIM: Hello. My name is Samar Ibrahim. I'm one of pediatric hepatologists at Mayo Clinic. I am here today to speak about the care we provide for pediatric patients with primary sclerosing cholangitis at the Pediatric Liver Transplant Center.

Primary sclerosing cholangitis is a chronic liver disease. It affects the bile ducts and the liver. It's a progressive disease, which means it will get worse with time. The rate of progression of the disease from one patient to another is variable, but the etiology or the cause behind the disease is not known. And there is no known therapeutic agent that can halt disease progression or improve prognosis. So the definitive treatment remains liver transplantation for patients with primary sclerosing cholangitis and end-stage liver disease.

At Mayo Clinic, we have a long experience caring for patients with primary sclerosing cholangitis in the pediatric age group. Our survival for a patient who had liver transplantation for end-stage liver disease secondary to primary sclerosing cholangitis on the short term or long term has been 100%. We evaluate patients with primary sclerosing cholangitis end-stage liver disease for the need of liver transplantation. We have a multidisciplinary team, and we assure that we manage the patient's complications and treat the symptoms during this critical period.

Treatment option will be mainly medical treatment and intervention by our endoscopist. We also do have a well-developed living related liver donor program, and we offer to individuals who are interested in being a living donor to their loved one with primary sclerosing cholangitis the opportunity to be screened to determine if they are an adequate candidate to be a liver donor and, we fully inform them about the process of living donation.

Primary sclerosing cholangitis

Samar Ibrahim, M.B., Ch.B., pediatric hepatologist at Mayo Clinic, discusses liver transplantation as a definitive treatment for primary sclerosing cholangitis (PSC).

Mayo Clinic practices a multidisciplinary approach to assure nutritional support and management of complications for pretransplant patients. Short- and long-term patient survival for pediatric patients undergoing transplant for PSC is 100 percent at Mayo Clinic.

A Living Liver Donor Program also is offered, which allows individuals to be screened as potential donors for their loved ones who are in need of a liver transplant.


Published

October 3, 2012

Created by

Mayo Clinic